Calpain inhibition preserves myocardial structure and function following myocardial infarction
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چکیده
منابع مشابه
Calpain inhibition preserves myocardial structure and function following myocardial infarction.
Cardiac pathology, such as myocardial infarction (MI), activates intracellular proteases that often trigger programmed cell death and contribute to maladaptive changes in myocardial structure and function. To test whether inhibition of calpain, a Ca(2+)-dependent cysteine protease, would prevent these changes, we used a mouse MI model. Calpeptin, an aldehydic inhibitor of calpain, was intraveno...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2009
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00338.2009